Sodium Hyaluronate, EP is a viscosity enhancer excipient. Chemical products are manufactured, packaged and stored under current Good Manufacturing Practices (cGMP). It has multiple medical uses as - Intra-articular injection, Intraocular viscoelastic injection, Skin injections in plastic surgery Topical application It is a carbohydrate which occurs naturally throughout the human body. It can be several thousands of sugars (carbohydrates) long. When not bound to other molecules, it binds to water giving it a stiff viscous quality similar to “Jello”. This viscous Gel is one of the most heavily researched substances in medicine today with thousands of clinical trials mostly in the fields of orthopedics and eye surgery. Its function in the body is, amongst other things, to bind water and to lubricate movable parts of the body, such as joints and muscles. Its consistency and tissue-friendliness allows it to be used in skin-care products as an excellent moisturizer. Hyaluronic acid is one of the most hydrophilic (water-loving) molecules in nature and can be described as “nature’s moisturizer”.
Applications for sodium hyaluronate include eye drops, contact lens solution, topical preparations, cell culture media and oral pharmaceutical preparations. We can support with full technical dossier docs for regulatory market along with very competitive price and commercial supply sustainability
Nowadays, HPBCD is the most versatile excipient among the cyclic oligosaccharides; it can be used in oral, rectal, dermal, ocular, and parenteral formulations. There are several marketed pharmaceutical products containing HPBCD with various active ingredients. The formulations are mostly solutions (infusion, injection, and eye drops) utilizing the solubilizing and stabilizing effect of HPBCD. HPBCD administered parenterally as a solubilizer of a poorly soluble drug.
The solubility of lipophilic drugs increases linearly with the concentration of hydroxypropyl-β-cyclodextrin (HBC) in aqueous solution because of the complex between HBC and the drug. This guest-host type complex is formed between the drug and the non-polar cavity in the HBC that results in enhanced solubility. Solutions may be lyophilized to produce freely soluble powders. Contact us for free samples and more information on and how it may serve your application.